Osteoporosis (osteoporosis), an autoimmune disease characterized by bone loss and impaired bone density, is the most common type of fracture in the United States (US) and most likely to affect individuals at high risk. There are currently no effective therapies that directly address osteoporosis or its impact on bone density. While oral treatment with ibuprofen or celecoxib has been shown to be effective, there are concerns that there may be increased risks of cardiovascular disease and fractures. This study evaluated the impact of naproxen (Aleve, Solvay) and cyclooxygenase-2 (COX-2) inhibitors on bone health and the risk of developing osteoporosis, both for osteoarthritis and osteoporosis in people at risk for the disease. It was hypothesized that celecoxib (Celebrex) and ibuprofen (Piroxant) may have potential to enhance bone mineral density in people with osteoporosis.
The purpose of this study was to evaluate whether naproxen and celecoxib were associated with a higher risk of osteoporosis compared to ibuprofen, cyclooxygenase-2 (COX-2) inhibitors, and COX-2 inhibitors alone. We hypothesized that celecoxib and ibuprofen may enhance bone mineral density (BMD) with similar mechanisms of action.
The primary objective of this study was to evaluate the effects of naproxen, celecoxib, and cyclooxygenase-2 (COX-2) inhibitors on bone mineral density (BMD) in people with osteoarthritis, an autoimmune disorder characterized by increased inflammation and loss of bone. We also included those who did not have an autoimmune disease, such as rheumatoid arthritis or autoimmune diseases. We included participants with a body mass index (BMI) of greater than 25 kg/m2, who were using a 0.2 mg/day oral dose of naproxen and/or celecoxib or cyclooxygenase-2 (COX-2) inhibitors. We also included those with a BMI of less than 25 kg/m2 who had evidence of osteoarthritis, or who were using rheumatoid arthritis and osteoporosis for at least 12 months. The primary outcome was the difference in the rate of change in the bone mineral density (BMD) at month 12. Secondary objectives included the change in BMD over the entire year from baseline to month 12. We also evaluated the effects of the treatments on the change in BMD over time.
We reviewed the full study dataset of participants for the purpose of this study. The study was conducted in the US. Participants were required to be at high risk for osteoporosis or osteoarthritis at the time of the study.
We excluded participants who were diagnosed with osteoarthritis or osteoarthritis in the last year of the study or those who did not have an autoimmune disease, such as rheumatoid arthritis or autoimmune diseases. Participants were excluded if they had a body mass index (BMI) ≥25 kg/m2, had no known cardiovascular disease, were on any chronic medical illness or had received any drug, or had a known or suspected family history of cardiovascular disease, stroke, or cardiovascular disease. We excluded participants with an estimated body surface area (EBI) of less than 0.5 m2 or those who had at least 1 hip fracture, have had at least one cardiovascular event (heart attack, stroke, or congestive heart failure), or had a history of any kind of vascular disease, malignancy, or cancer. In addition, participants were excluded if they had a BMI of greater than 25 kg/m2, were diagnosed with any type of breast cancer, had a history of blood clot, or had a history of bone marrow disorder. We excluded participants who were on any type of medications, were receiving any form of or non-steroidal anti-inflammatory drug (NSAID), or were taking any form of vitamin or mineral supplement.
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Medicine InformationRisk of getting severe or fatal respiratory or kidney complications from Celebrex, or any similar painkillers, may be increased by combining the Celebrex with another drug that inhibits cyclooxygenase 2. Celebrex is contraindicated in patients with a known hypersensitivity to any of its components. Celebrex is also not recommended for use in patients who have previously had an organ transplant, or who are pregnant or nursing. Celebrex should be used in accordance with local official prescribing information and guidelines as directed by your doctor. Celebrex should not be taken with blood thinners, calcium supplements or iron supplements, as this combination may cause a severe reaction when taken with Celebrex. Celebrex may increase your risk of getting a stroke or cause you to be dehydrated. In addition, you may need to have a blood pressure check before you can take Celebrex. This risk may increase if Celebrex is taken with a blood pressure-lowering drug, such as a diuretic (water pill), as it may decrease your blood pressure. If you need to get extra blood work, you should combine Celebrex with a substitute like iodinated salt such as sodium iodide. This may increase your risk of side effects. Please do not drink alcohol while taking Celebrex. Celebrex can increase your risk of getting an infection. This medicine is not indicated in women or children. Celebrex may rarely cause a severe allergic reaction. Continue your doctor's advice on the risks and benefits of this medicine even if you can tell the difference. If you have a serious underlying medical condition, like high blood pressure, heart failure, epilepsy or a stroke, you should contact a doctor. Celebrex may rarely cause a severe skin reaction, such as exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis or liver injury. Symptoms of a serious skin reaction may include: skin rash, itching, redness, blistering and peeling. If you notice anything unusual, contact your doctor or pharmacist within 6 months of giving Celebrex. In case of overdose or suspected overdose, get medical help or contact a Poison Control Centre 24/7. Celebrex can also cause other serious side effects, such as chest pain, nausea, shortness of breath and fainting. If you experience any of these symptoms while taking Celebrex, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. - US - Call your doctor for medical advice about side effects. You may report side effects to st. 1-866-FDA-1088. US - Call your doctor for medical advice about side effects. You may not. 1-800-FDA-1088. UK - Call 1-888-374-4022 for emergency medical advice. US - Call 1-800-FDA-P • US - Call 1-866-FDA-P • UK - Fax No. 1, Tel: 1. Once a month • UK - Fax No.
CELEBREX 200MG CAPSULE contains Celecoxib which belongs to group of medicines called Non-steroidal anti-inflammatory drugs. CELEBREX 200MG CAPSULE is used in adults to manage osteoarthritis (degenerative joint disease), rheumatoid arthritis (inflammatory disease of joints), ankylosing spondylitis (chronic back pain), acute pain and primary dysmenorrhea (menstrual cramps).
CELEBREX 200MG CAPSULE is also used to manage juvenile rheumatoid arthritis (in children aged 2 years and above).
CELEBREX 200MG CAPSULE is not recommended for use in patients allergic to Celecoxib, sulfonamides, aspirin and/or other NSAIDs. It is also not recommended for use in patients with/had a history of an ulcer in stomach/intestines, bleeding in stomach/intestines, blood circulation problems (such as peripheral arterial disease), red itchy welts, inflammatory disease of the intestines (such as ulcerative colitis/Crohn’s disease).
The medicine is also not indicted for use in patients suffering from lung problems (such as asthma), heart diseases (such as heart failure, recent heart attack, heart block), severe liver disease (such as advanced hepatic insufficiency) and/or kidney disease (such as advanced renal insufficiency).
Before taking CELEBREX 200MG CAPSULE, inform your doctor if you have diabetes, raised blood pressure, increased cholesterol, signs of fluid retention (such as swollen ankles and feet) and/or hyperkalemia (increased potassium level in blood).
CELEBREX 200MG CAPSULE is not recommended for use in pregnant and breast-feeding women.
CELEBREX 200MG CAPSULE should be used with caution in children and adolescents (aged 2 to 17 years) to manage only juvenile rheumatoid arthritis and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness. Consult your doctor if any of these symptoms worsen.
regular exerciseDo not increase your dose or use CELEBREX 200MG CAPSULE if you are hypersensitive to it
bloody or hard of mouthCELEBREX 200MG CAPSULE is not recommended for use in patients with a history of nausea and/or vomiting and/or a rapid heartbeat (companion 4).
There are many side effects of taking it. The more severe the side effect, the more likely you’ll experience these side effects like chest pain, shortness of breath, a burning in your eyes, muscle weakness, pain in your arms and legs, allergic reaction and/or rash.
It’s best to avoid taking it when you are loss of appetite, especially if you are taking you prior to receiving any treatment with Celecoxib. If you are affected by this side effect, discuss with the doctor if you are willing and able to use it.
Take it at the same time each day as your daily dose is taken. If you missed your dose, take it as soon as you remember. Do not take a double dose to make up for the missed dose.
Side effects of CELEBREX 200MG CAPSULE
It’s important to mention that CELEBREX 200MG CAPSULE may cause serious skin reactions like contact dermatitis, Stevens-Johnson syndrome, toxic epidermala/oesophagitis, exfoliative dermatitis and/or other serious reactions like exfoliative diseases of the skin including Stevens Johnson syndrome, toxic epidermal necrolysis and EMC. In case of these serious reactions, immediately seek medical attention.
What is Celebrex?
Celebrex, also known as Celecoxib, is an FDA-approved nonsteroidal anti-inflammatory drug (NSAID) that works to relieve pain, reduce inflammation, and lower blood pressure. Celebrex is used for:
What is Celebrex 200?
Celebrex 200mg is an NSAID that helps reduce pain and inflammation. It belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
Celebrex may decrease the swelling of joints and lower blood pressure. It can also reduce fever. Celebrex is often used to treat pain caused by arthritis and osteoarthritis.
Celebrex 200mg is a prescription medication that is taken every day for long-term use to reduce the risk of stomach ulcers, bleeding, and other serious side effects. It can be taken with or without food. The maximum daily dose is usually 400 mg. This drug is also known as Celecoxib, which means it belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs).
What conditions is Celebrex 200 approved to treat?
Celebrex 200mg is approved to treat:
Celebrex 200mg is not approved for the treatment of:
How is Celebrex given?
Celebrex should be taken with a full glass of water, as this helps to prevent stomach irritation and ulcers. If you are taking this medication, it is important to follow the directions on the prescription label carefully, and to take it regularly. Do not stop taking Celebrex without talking to your doctor. Take Celebrex at the same time every day for the same amount of time. If you forget to take it, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at the same time.
What are the possible side effects?
Common side effects of Celebrex 200 mg include:
What are the possible drug interactions?
You should not take Celebrex 200 mg if you are allergic to the active ingredient in Celebrex, or if you are taking other NSAIDs.
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